oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen arachidonate 8(S)-lipoxygenase activity https://github.com/geneontology/go-ontology/issues/30193 molecular_function KEGG_REACTION:R07053 This activity produces the S-enantiomer of HPETE, 8(S)-HPETE. For the reaction producing the S-enantiomer, see GO:0047677. bf GO:0036403 RHEA:38675 8(S)-lipoxygenase activity 8-lipoxygenase (S-type) Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. 2013-08-14T11:48:46Z