endoplasmic reticulum unfolded protein response IRE1-mediated unfolded protein response IRE1 signaling in response to endoplasmic reticulum stress IRE1alpha unfolded protein response biological_process The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. IRE1 signal transduction pathway inositol-requiring enzyme 1-mediated unfolded protein response endoplasmic reticulum unfolded protein response; IRE1 signaling Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants. inositol-requiring transmembrane kinase/endonuclease signal transduction ERN1-mediated unfolded protein response IRE1p unfolded protein response bf GO:0036498 Reactome:R-HSA-381070 2015-02-05T13:12:12Z UPR signaling by IRE1 stress sensor IRE1 branch of UPR