ER-nucleus signaling pathway endoplasmic reticulum unfolded protein response ATF6-mediated unfolded protein response 2015-02-05T13:18:58Z biological_process activating transcription factor 6 signaling in unfolded protein response UPR signaling by ATF6 stress sensor endoplasmic reticulum unfolded protein response; ATF6 signaling ATF6 branch of UPR Reactome:R-HSA-381033 GO:0036500 ATF6 signaling in response to endoplasmic reticulum stress The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. ATF6 signal transduction pathway bf ATF6-beta UPR branch ATF6-alpha UPR branch