negatively regulates signal transduction negative regulation of signal transduction receptor internalization regulation of signal transduction by receptor internalization negative regulation of signal transduction by receptor internalization GO:0038011 biological_process bf 2011-06-23T03:39:06Z Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands. negative regulation of signaling pathway by receptor endocytosis