negatively regulates insulin receptor signaling pathway negative regulation of signal transduction by receptor internalization negative regulation of insulin receptor signaling pathway by insulin receptor internalization GO:0038014 2011-06-23T04:08:31Z negative regulation of insulin receptor signalling pathway by insulin receptor internalization biological_process agonist-stimulated insulin receptor internalization bf Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation. insulin receptor internalization negative regulation of insulin receptor signaling pathway