nitric oxide-cGMP-mediated signaling nitric oxide-cGMP-mediated signaling pathway nitric oxide-cGMP-mediated signal transduction NO-cGMP signaling pathway classical nitric oxide signaling canonical nitric oxide signaling An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP. bf biological_process nitric oxide-cGMP-mediated signalling pathway 2012-01-10T05:32:39Z GO:0038060 intracellular signaling cassette