non-canonical NF-kappaB signal transduction https://github.com/geneontology/go-ontology/issues/22415 https://github.com/geneontology/go-ontology/issues/25583 p52-dependent NF-kappaB signaling noncanonical nuclear factor kappaB (NF-kappaB) pathway noncanonical NF-kappaB signaling NIK-IKK signaling pathway NIK/NF-kappaB signal transduction NIK-IKK-alpha cascade GO:0038061 NF-kappaB cascade NIK-IKK kinase cascade NIK/NF-kappaB cascade bf biological_process An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). NIK/NF-kappaB signaling 2012-01-16T05:44:46Z Reactome:R-HSA-5676590 non-canonical NF-KB signaling intracellular signaling cassette