part of cell surface receptor protein tyrosine kinase signaling pathway cytokine-mediated signaling pathway cellular response to stem cell factor stimulus Kit signaling pathway 2012-03-22T10:09:48Z GO:0038109 stem cell factor receptor signaling pathway Kit signalling pathway SCF signaling pathway bf The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell. biological_process stem cell factor signaling pathway