obsolete suppression by virus of host MAVS activity by MAVS proteolysis true GO:0039546 viral protease cleavage of MAVS OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling. biological_process The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. 2012-01-19T02:49:44Z bf