symbiont-mediated suppression of host JAK-STAT cascade symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity https://github.com/geneontology/go-ontology/issues/21986 https://github.com/geneontology/go-ontology/issues/26686 This term is for annotation of symbiont proteins that counteract the host innate immune response. inhibition of host interferon regulatory factor-9 by virus suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity 2012-03-09T04:42:08Z bf GO:0039560 inhibition of host IRF9 by virus suppression by virus of host IRF9 activity disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity VZ:683 A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. For example, viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes. suppression by virus of host interferon regulatory factor 9 activity biological_process symbiont-mediated suppression of host innate immune response