symbiont-mediated suppression of host JAK-STAT cascade symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity https://github.com/geneontology/go-ontology/issues/21963 https://github.com/geneontology/go-ontology/issues/26686 2012-03-12T02:28:39Z suppression by virus of host signal transducer and activator of transcription activity biological_process inhibition by virus of host STAT activity A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes. This term is for annotation of symbiont proteins that counteract the host innate immune response. suppression by virus of host JAK-STAT cascade via inhibition of STAT activity bf GO:0039562 disruption by virus of host JAK-STAT cascade via inhibition of STAT activity suppression by virus of host STAT activity