symbiont-mediated suppression of host JAK-STAT cascade symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity https://github.com/geneontology/go-ontology/issues/21986 https://github.com/geneontology/go-ontology/issues/26686 suppression by virus of host TYK2 activity GO:0039574 VZ:720 disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits. suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity biological_process bf This term is for annotation of symbiont proteins that counteract the host innate immune response. symbiont-mediated suppression of host innate immune response