PKR/eIFalpha signaling https://github.com/geneontology/go-ontology/issues/26502 GO:0039585 EIF2AK2/PRK signaling EIF2AK2 signal transduction 2012-05-02T04:15:10Z PKR signal transduction PKR signaling pathway biological_process signaling through PKR Reactome:R-HSA-9833482 bf An intracellular signaling cassette that starts with activation and autophosphorylation of PKR (also known as EIF2AK2), which phosphorylates proteins including the translation initiation factor eIF2 to inhibit translation. PKR is activated by stress signals and during the antiviral response, activated by binding to viral double-stranded RNA (dsRNA) leading to inhibition of protein synthesis during viral infection. integrated stress response signaling