translesion synthesis error-prone translesion synthesis error-prone postreplication DNA repair Reactome:R-HSA-5656121 The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. Reactome:R-HSA-110312 biological_process Reactome:R-HSA-5655862 GO:0042276 mutagenic postreplication DNA repair mutagenic PRR