GDP-mannose metabolic process GDP-L-fucose biosynthetic process 'de novo' GDP-L-fucose biosynthetic process https://github.com/geneontology/go-ontology/issues/25823 https://github.com/geneontology/go-ontology/issues/28825 biological_process GO:0042351 GDP-L-fucose biosynthetic process, de novo pathway 'de novo' GDP-L-fucose anabolism 'de novo' GDP-L-fucose biosynthesis MetaCyc:PWY-66 'de novo' GDP-L-fucose synthesis The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271). 'de novo' GDP-L-fucose formation GDP-L-fucose biosynthesis, de novo pathway