negatively regulates negative regulation of glycoprotein biosynthetic process amyloid precursor protein biosynthetic process regulation of amyloid precursor protein biosynthetic process negative regulation of amyloid precursor protein biosynthetic process down-regulation of amyloid precursor protein biosynthetic process negative regulation of APP biosynthesis downregulation of amyloid precursor protein biosynthetic process biological_process negative regulation of APP biosynthetic process negative regulation of amyloid precursor protein anabolism negative regulation of amyloid precursor protein formation negative regulation of amyloid precursor protein synthesis Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. negative regulation of amyloid precursor protein biosynthesis GO:0042985 inhibition of amyloid precursor protein biosynthetic process down regulation of amyloid precursor protein biosynthetic process biological regulation