part of DNA replication factor C complex cytoplasm cytoplasmic DNA replication factor C complex cytoplasmic RFC GO:0043598 cytoplasmic clamp loader A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species. cellular_component cytoplasmic replisome