obsolete interaction with host via substance released by symbiont cytolysis true biological_process This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. GO:0044051 interaction with host via substance released by cytolysis of symbiont OBSOLETE. An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.