epigenetic programming in the zygotic pronuclei epigenetic programing of female pronucleus https://github.com/geneontology/go-ontology/issues/24543 jl 2012-10-24T14:10:36Z biological_process The global programming of epigenetic modifications in the female pronucleus of the newly fertilized zygote. The maternal genome is protected from global DNA demethylation before the first division of the zygote, and instead undergoes passive, replication-dependent demethylation during early embryogenesis, arising from inhibition of the DNA maintenance methyltransferase Dnmt1. protection of DNA methylation in female pronucleus protection of DNA demethylation of female pronucleus GO:0044726 maintenance of DNA methylation at imprinted genes