epigenetic programming in the zygotic pronuclei epigenetic programing of male pronucleus The global programming of epigenetic modifications in the male pronucleus of the newly fertilized zygote. The most major change in the paternal genome is DNA demethylation, which takes place before the first cell division. GO:0044727 2012-10-24T14:25:35Z epigenetic reprograming of male pronucleus DNA demethylation of male pronucleus epigenetic reprograming of paternal genome in zygote jl biological_process