part of endoplasmic reticulum organization protein localization to organelle protein insertion into ER membrane localization of protein in ER membrane GO:0045048 biological_process positioning of protein in ER membrane protein-endoplasmic reticulum insertion protein insertion into endoplasmic reticulum membrane Reactome:R-HSA-9609523 integral ER membrane protein positioning integral ER membrane protein localization protein-ER insertion The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. protein insertion into membrane