obsolete cytosolic pyruvate dehydrogenase complex https://github.com/geneontology/go-ontology/issues/26122 true GO:0045250 cellular_component pyruvate dehydrogenase complex (lipoamide) OBSOLETE. A cytosolic complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. This term is unnecessarily taxon-specific. pyruvate dehydrogenase complex