alpha-ketoacid dehydrogenase complex pyruvate dehydrogenase complex https://github.com/geneontology/go-ontology/issues/24350 https://github.com/geneontology/go-ontology/issues/26122 https://github.com/geneontology/go-ontology/issues/26881 cellular_component GO:0045254 The catalytic activities of the individual components of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (acetyl-transferring) activity ; GO:0004739' (E1), 'dihydrolipoyllysine-residue acetyltransferase activity ; GO:0004742' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. Wikipedia:Pyruvate_dehydrogenase_complex GO:0009364 pyruvate dehydrogenase complex (lipoamide) acetyltransferase complex