negatively regulates regulation of mitotic nuclear division negative regulation of cell cycle process negative regulation of mitotic nuclear division down-regulation of mitosis down regulation of mitosis biological_process GO:0045839 negative regulation of mitosis inhibition of mitosis Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. downregulation of mitosis negative regulation of mitotic cell cycle negative regulation of nuclear division biological regulation mitotic nuclear division