negatively regulates nucleobase-containing compound metabolic process negative regulation of metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of nucleobase-containing compound metabolic process https://github.com/geneontology/go-ontology/issues/31498 Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process biological_process down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process biological regulation