1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity https://github.com/geneontology/go-ontology/issues/28336 https://github.com/geneontology/go-ontology/issues/30193 Reactome:R-HSA-1226014 Reactome:R-HSA-5654701 Reactome:R-HSA-1306957 Reactome:R-HSA-5655235 molecular_function Reactome:R-HSA-177939 Reactome:R-HSA-1676048 Reactome:R-HSA-1250462 Reactome:R-HSA-186800 MetaCyc:2.7.1.153-RXN Reactome:R-HSA-392300 Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + H+. RHEA:43396 Reactome:R-HSA-5654714 Reactome:R-HSA-5655323 Reactome:R-HSA-5218819 Reactome:R-HSA-9021627 phosphatidylinositol 3-kinase activity, class II Reactome:R-HSA-2076220 Reactome:R-HSA-2424480 Reactome:R-HSA-5655289 Reactome:R-HSA-2730870 Reactome:R-HSA-9603445 Reactome:R-HSA-9665407 phosphatidylinositol-4,5-bisphosphate 3-kinase activity Reactome:R-HSA-5654709 Reactome:R-HSA-2029271 Reactome:R-HSA-9712084 Reactome:R-HSA-5654705 Reactome:R-HSA-5637801 phosphatidylinositol 3-kinase activity, class I Reactome:R-HSA-8852019 Reactome:R-HSA-1306979 Reactome:R-HSA-9860816 Reactome:R-HSA-5655290 Reactome:R-HSA-389158 Reactome:R-HSA-9672177 Reactome:R-HSA-1839107 EC:2.7.1.153 RHEA:21292 Reactome:R-HSA-5654717 type I phosphoinositide 3-kinase activity Reactome:R-HSA-5654697 GO:0046934 Reactome:R-HSA-1839091 Reactome:R-HSA-9664664 Reactome:R-HSA-437162 Reactome:R-HSA-9664940 Reactome:R-HSA-5654692 Reactome:R-HSA-202365 Reactome:R-HSA-201510 Reactome:R-HSA-5654690 Reactome:R-HSA-9028519 RHEA:55632 Reactome:R-HSA-2316434 KEGG_REACTION:R04545 Reactome:R-HSA-9672162 Reactome:R-HSA-2394007 phosphatidylinositol 3-kinase, class I, catalyst activity Reactome:R-HSA-198266 Reactome:R-HSA-1250370 phosphatidylinositol kinase activity