steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor pregnan-21-ol dehydrogenase (NADP+) activity 21-hydroxysteroid dehydrogenase (NADP+) activity 21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity KEGG_REACTION:R03044 21-hydroxy steroid dehydrogenase activity Catalysis of the reaction: NADP+ + pregnan-21-ol = H+ + NADPH + pregnan-21-al. 21-hydroxysteroid:NADP+ 21-oxidoreductase activity GO:0047008 molecular_function NADP-21-hydroxysteroid dehydrogenase activity EC:1.1.1.151 MetaCyc:1.1.1.151-RXN RHEA:23712 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity