oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity https://github.com/geneontology/go-ontology/issues/30193 GO:0047033 (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity PG I2 dehydrogenase activity NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity KEGG_REACTION:R03520 molecular_function MetaCyc:1.1.1.231-RXN RHEA:21420 NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity EC:1.1.1.231 prostacyclin dehydrogenase activity Catalysis of the reaction: NADP+ + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H+ + NADPH.