enone reductase activity Delta4-3-oxosteroid 5beta-reductase activity https://github.com/geneontology/go-ontology/issues/27695 https://github.com/geneontology/go-ontology/issues/28526 RHEA:47080 cortisone delta4-5beta-reductase activity Delta4-hydrogenase activity Delta4-3-ketosteroid 5beta-reductase activity Delta(4)-3-ketosteroid 5-beta-reductase activity RHEA:46636 Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates. RHEA:46672 RHEA:46632 Delta4-3-oxosteroid 5-beta-reductase activity RHEA:54412 cholestenone 5beta-reductase activity RHEA:14037 MetaCyc:CORTISONE-BETA-REDUCTASE-RXN cortisone 5beta-reductase activity RHEA:11524 molecular_function androstenedione 5-beta-reductase activity MetaCyc:RXN-23672 RHEA:46668 3-oxo-Delta(4)-steroid 5-beta-reductase activity cortisone 5-beta-reductase activity RHEA:46660 testosterone 5beta-reductase activity MetaCyc:RXN-9726 Delta4-5beta-reductase activity RHEA:46664 5-beta-reductase activity 5beta-reductase activity 4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity cortisone delta(4)-5-beta-reductase activity cortisone beta-reductase activity RHEA:46656 cholestenone 5b-reductase activity GO:0047752 steroid 5-beta-reductase activity steroid 5beta-reductase activity RHEA:46652 Delta(4)-5-beta-reductase activity testosterone 5-beta-reductase activity 3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity androstenedione 5beta-reductase activity 3-oxo-Delta4-steroid 5beta-reductase activity 5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity cholestenone 5-beta-reductase activity RHEA:46644 cortisone b-reductase activity MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN Delta(4)-hydrogenase activity EC:1.3.1.3 GO:0047787 RHEA:46640