'de novo' protein folding 'de novo' post-translational protein folding Reactome:R-HSA-391251 GO:0051084 The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. biological_process 'de novo' posttranslational protein folding