obsolete cofactor catabolic process true cofactor degradation 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. biological_process cofactor catabolism OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. cofactor breakdown GO:0051187