obsolete cofactor biosynthetic process true OBSOLETE. The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. cofactor synthesis cofactor biosynthesis cofactor anabolism 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. GO:0051188 cofactor formation biological_process