protein methylesterase activity https://github.com/geneontology/go-ontology/issues/27558 GO:0051723 PME activity Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol. Reactome:R-HSA-8856951 MetaCyc:RXN-12322 protein methyl-esterase activity molecular_function protein carboxylic ester hydrolase activity protein carboxyl methylesterase activity EC:3.1.1.89 Reactome:R-HSA-5367022 RHEA:48548 carboxylic ester hydrolase activity catalytic activity, acting on a protein