negatively regulates phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction https://github.com/geneontology/go-ontology/issues/25656 downregulation of protein kinase B signaling cascade negative regulation of AKT signaling cascade Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. negative regulation of PI3K/PKB signal transduction negative regulation of protein kinase B signaling cascade inhibition of protein kinase B signaling cascade negative regulation of PKB signalling cascade negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction negative regulation of PI3K-PKB/Akt pathway negative regulation of PI3K/Akt signal transduction GO:0051898 down-regulation of protein kinase B signaling cascade negative regulation of AKT signalling cascade down regulation of protein kinase B signaling cascade negative regulation of PKB signaling cascade negative regulation of protein kinase B signaling negative regulation of protein kinase B signalling cascade biological_process biological regulation negative regulation of intracellular signal transduction