L-lysine biosynthetic process obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate https://github.com/geneontology/go-ontology/issues/30820 https://github.com/geneontology/go-ontology/issues/31525 true The reason for obsoletion is that this term represents a GO-CAM model. OBSOLETE. The chemical reactions and pathways resulting in the formation of L-lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine. lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate biological_process GO:0051976