symbiont-mediated perturbation of host immune response symbiont-mediated suppression of host immune response negative regulation by organism of immune response of other organism involved in symbiotic interaction A process in which a symbiont interferes with, inhibits or disrupts the normal execution of an immune response of the host organism. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. suppression by symbiont of host immune response negative regulation by symbiont of host immune response down-regulation by symbiont of host immune response inhibition by symbiont of host immune response down regulation by symbiont of host immune response downregulation by symbiont of host immune response biological_process GO:0052561 GO:0052562