cuticular extracellular matrix https://github.com/geneontology/go-ontology/issues/29265 cellular_component collagen and cuticulin-based exoskeleton extracellular matrix GO:0060102 cuticular ECM A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans. collagen and cuticulin-based cuticle extracellular matrix specialized extracellular matrix