negatively regulates penile erection negative regulation of multicellular organismal process regulation of penile erection negative regulation of penile erection Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. biological_process GO:0060407 biological regulation negative regulation of reproductive process