negatively regulates mesonephros development regulation of mesonephros development negative regulation of mesonephros development GO:0061218 biological_process dph 2010-08-17T03:43:06Z Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. biological regulation negative regulation of kidney development