regulates premature acrosome loss regulation of premature acrosome loss Any process that modulates the rate, frequency or extent of the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. 2017-10-25T17:51:32Z biological_process dph GO:0061949 biological regulation regulation of reproductive process