negatively regulates premature acrosome loss regulation of premature acrosome loss negative regulation of premature acrosome loss dph Any process that stops, prevents or reduces the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. GO:0061950 biological_process 2017-10-25T17:56:47Z negative regulation of spontaneous acrosome loss biological regulation negative regulation of reproductive process