2-oxoglutarate-dependent dioxygenase activity DNA 5-methylcytosine dioxygenase activity https://github.com/geneontology/go-ontology/issues/23312 https://github.com/geneontology/go-ontology/issues/24855 https://github.com/geneontology/go-ontology/issues/26656 https://github.com/geneontology/go-ontology/issues/29854 RHEA:53832 Reactome:R-HSA-9817458 2009-04-22T02:29:41Z Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC). methylcytosine dioxygenase activity WIkipedia:DNA_demethylation Reactome:R-HSA-5221014 This reaction removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidised base by the base excision repair system. Do not confuse with oxidative DNA demethylase activity ; GO:0035516, which directly reverses the alkylation on nucleotides in the DNA. RHEA:53828 RHEA:52636 GO:0070579 EC:1.14.11.80 Reactome:R-HSA-5220952 molecular_function Reactome:R-HSA-5220990 mah catalytic activity, acting on DNA