part of distal convoluted tubule development metanephric distal convoluted tubule development biological_process mah 2010-03-18T03:35:27Z The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. GO:0072221 metanephric nephron tubule development metanephric distal tubule development