part of proximal convoluted tubule segment 2 development metanephric proximal convoluted tubule development metanephric proximal convoluted tubule segment 2 development metanephric S2 development The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride. biological_process mah GO:0072232 2010-03-18T03:39:28Z