G protein-coupled acetylcholine receptor signaling pathway negative regulation of heart rate obsolete G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate https://github.com/geneontology/go-ontology/issues/31254 true biological_process G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate M2 receptor signalling pathway involved in negative regulation of heart rate 2011-11-11T03:11:58Z muscarinic receptor signalling pathway involved in negative regulation of heart rate This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model. OBSOLETE. A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate. muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate tb GO:0086033