negatively regulates release of cytochrome c from mitochondria negative regulation of organelle organization biological regulation regulation of release of cytochrome c from mitochondria negative regulation of release of cytochrome c from mitochondria biological_process The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process. 2009-12-18T11:35:20Z tb GO:0090201 Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. negative regulation of apoptotic signaling pathway