part of exocytosis vesicle tethering involved in exocytosis tb 2013-01-08T15:07:50Z The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. vesicle tethering to plasma membrane biological_process GO:0090522 vesicle tethering exocytic process