agmatine biosynthetic process agmatine biosynthesis agmatine synthesis pr The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. agmatine anabolism biological_process agmatine formation 2011-05-25T03:56:17Z Reactome:R-HSA-351143 GO:0097055 primary amino compound biosynthetic process