cell surface receptor signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in presence of ligand Reactome:R-HSA-5357769 extrinsic apoptosis death receptor-mediated apoptosis pr Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer. biological_process GO:0097191 The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. extrinsic apoptotic signalling pathway 2011-11-23T09:34:28Z extrinsic apoptotic pathway