part of intracellular signal transduction cellular response to hypoxia hypoxia-inducible factor-1alpha signaling pathway https://github.com/geneontology/go-ontology/issues/28069 HIF1alpha pathway hypoxia-inducible factor signaling pr 2012-11-06T10:46:33Z biological_process The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. hypoxia-inducible factor-1alpha signalling pathway GO:0097411